By Frank J. Dixon
"The sequence which all immunologists need." --The Pharmaceutical magazine "Advances in Immunology needs to locate itself one of the so much energetic volumes within the libraries of our universities and institutions." --Science "Deserves an enduring position in biomedical libraries as an reduction in study and in instructing" --Journal of Immunological tools "A provocative and scholarly evaluation of analysis" --Journal of the yankee clinical organization "Provides a really helpful resource of reference and lots of stimulating ideas...the major repository of data in a quickly devloping topic" --The Lancet "Provides unrivalled price in either educational and financial phrases and may be bought by means of tough pressed librarians as an immense precedence to be jealously defended." --Journal of scientific Microbiology "A very beneficial serial publication...no critical scholar of immunology can find the money for to be with out it." --Archives of Biochemistry and Biophysics Key positive factors * specialize in parts of the V(D)J recombination equipment that will be regarding ailments in people and animals * regulate of the supplement process by way of regulate of C3/C5 convertase on host cells, regulate of fluid section C3/C5 convertases, keep watch over of fluid section MAC, and keep an eye on of deposited MAC * Immunodeficiency because of an entire absence of MHC category II expression and trans-acting components controlling transcription * present wisdom of IL-2R signaling, highlighting IL-2 signaling, and T-cell development rules * useful function of CD40 in cells, the in vivo value of CD40-CD40-L interactions, and the sign transduction equipment activated following crosslinking of the CD40 antigen * Integrative method of higher comprehend the saw heterogeneity of a person reaction to allergens * legislation of isotype specificity, swap recombination rules, and the mechanism of switching * lymphocyte-specific proteins, RAG1 and RAG2, start up V(D)J recombination of antigen receptor genes
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Extra info for Advances in Immunology, Vol. 61
This effect is observed early (24 hr) after triggering and occurs in the absence of cell proliferation. , manuscript in preparation). 10. , 1995). 11. , submitted for publication). )Iincreases fibroblast CD40 expression. CD40 ligation also results in increased production of GM-CSF and MIP-la by synoviocytes. Thus, as summarized in Fig. 9, CD40 appears to be functional on multiple cell types. VI. In Vivo Role of CD40-CD40-1 Interactions A. , I N THE 42 CEES VAN KOOTEN A N D JACQUES RANCHEHEAU Fic: 9.
1994),rendering them efficient APCs. , 1994). , 1994b), thus indicating the presence of a positive activation loop involving the B celVAPC CD40 and the T cell CD28. 2. Fas-Fas-L Pathway The interaction of Fas with Fas-L plays a pivotal role in the elimination of both T and B lymphocytes via apoptosis (Nagata and Golstein, 1995). , 1993), it is absent on naive B cells and only weakly expressed on memory B cells. , 1995). , 1995). , 1995), probably next to CD40-L, the delayed induction of apoptosis by Fas ligation might represent a way to limit the size of a specific B cell clone that is generated during T-B interactions.
Advances in Immunology, Vol. 61 by Frank J. Dixon